Drug Information

Drug General Information
Drug ID
D04QXG
Former ID
DNC001366
Drug Name
SR 120819A
Drug Type
Small molecular drug
Indication Eating disorder [ICD9: 278, 307.5, 401, 428.0; ICD10:E66, F50, I10-I16, I50] Terminated [534212], [538943]
Structure
Download
2D MOL

3D MOL
Formula
C43H54N6O4S
InChI
InChI=1S/C43H54N6O4S/c1-48(2)30-34-16-14-33(15-17-34)29-45-41(44)36-20-18-32(19-21-36)27-40(43(51)49-24-8-9-25-49)46-42(50)39(26-31-10-4-3-5-11-31)47-54(52,53)38-23-22-35-12-6-7-13-37(35)28-38/h3-7,10-13,18-23,28,33-34,39-40,47H,8-9,14-17,24-27,29-30H2,1-2H3,(H2,44,45)(H,46,50)/t33-,34+,39-,40-/m1/s1
InChIKey
GKKPXBHNFVDHAQ-GWOGJWAKSA-N
PubChem Compound ID
5312150
PubChem Substance ID
7980622, 7980623, 14815612, 39341768, 57359530, 76890842, 114158008, 134339390, 134340558, 135651070, 140191775, 247233707
Target and Pathway
Target(s) Neuropeptide Y receptor type 1 Target Info Antagonist [537861]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway FSH Signaling Pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
References
Ref 534212SR 120107A antagonizes neuropeptide Y Y1 receptor mediated sympathetic vasoconstriction in pigs in vivo. Eur J Pharmacol. 1996 Jun 3;305(1-3):145-54.
Ref 538943(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1530).
Ref 537861SR 120819A, an orally-active and selective neuropeptide Y Y1 receptor antagonist. FEBS Lett. 1995 Apr 3;362(2):192-6.

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