Drug Information

Drug General Information
Drug ID
D04RCG
Former ID
DIB006722
Drug Name
MEN-10627
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Terminated [540539], [545837]
Company
The Menarini Group
Structure
Download
2D MOL
Formula
C38H48N8O7S
InChI
InChI=1S/C38H48N8O7S/c1-21(2)15-27-34(49)41-26(13-14-54-3)33(48)45-30-18-32(47)40-20-31(38(53)42-27)46-35(50)28(16-22-9-5-4-6-10-22)43-36(51)29(44-37(30)52)17-23-19-39-25-12-8-7-11-24(23)25/h4-12,19,21,26-31,39H,13-18,20H2,1-3H3,(H,40,47)(H,41,49)(H,42,53)(H,43,51)(H,44,52)(H,45,48)(H,46,50)/t26-,27-,28-,29+,30+,31+/m0/s1
InChIKey
CFDNUNSOUUFTQO-JYMVZIKVSA-N
CAS Number
CAS 157351-81-0
PubChem Compound ID
5311274
PubChem Substance ID
7979899, 11056398, 39340973, 57359412, 78082294, 114155718, 178100735
Target and Pathway
Target(s) NK-2 receptor Target Info Modulator [533842]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Reactome G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 540539(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3901).
Ref 545837Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004991)
Ref 533842MEN 10,627, a novel polycyclic peptide antagonist of tachykinin NK2 receptors. J Pharmacol Exp Ther. 1994 Dec;271(3):1489-500.

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