Drug Information

Drug General Information
Drug ID
D04RDE
Former ID
DCL000459
Drug Name
AZD1940
Drug Type
Small molecular drug
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Discontinued in Phase 2 [548585]
Therapeutic Class
Analgesics
Company
AstraZeneca
Structure
Download
2D MOL

3D MOL
Formula
C32H39ClN6O7S
Canonical SMILES
CCCN1C2=C(C(=O)N(C1=O)CCC)NC(=N2)C34CC5CC(C3)CC4C5.C1=C<br />OC(=C1)CNC2=CC(=C(C=C2C(=O)O)S(=O)(=O)N)Cl
InChI
1S/C20H28N4O2.C12H11ClN2O5S/c1-3-5-23-16-15(17(25)24(6-4-2)19(23)26)21-18(22-16)20-10-12-7-13(11-20)9-14(20)8-12;13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h12-14H,3-11H2,1-2H3,(H,21,22);1-5,15H,6H2,(H,16,17)(H2,14,18,19)
InChIKey
LLLIKHLUUMWXPN-UHFFFAOYSA-N
PubChem Compound ID
9831419
PubChem Substance ID
14790564, 44929537, 79468804, 134339068, 134339093, 134340278
Target and Pathway
Target(s) Cannabinoid receptor 1 Target Info Agonist [550288]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
PANTHER Pathway Endogenous cannabinoid signaling
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
BDNF signaling pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 548585Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026807)
Ref 550288Clinical pipeline report, company report or official report of AstraZeneca (2009).

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