TTD | Drug: D04RUP

Drug General Information
Drug ID	D04RUP
Former ID	DIB001543
Drug Name	SDZ-NKT-343
Synonyms	NKT-343; SDZ-250343
Drug Type	Small molecular drug
Indication	Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89]		Discontinued in Phase 1	[546834]
Company	Novartis AG
Structure		Download 2D MOL 3D MOL
Formula	C33H33N5O5
Canonical SMILES	C(=O)(N1[C@H](C(=O)N[C@H](C(=O)N(Cc2ccccc2)C)Cc2cc3c(cc<br />2)cccc3)CCC1)Nc1c([N+](=O)[O-])cccc1
CAS Number	CAS 180046-99-5
PubChem Compound ID	9851211
Target and Pathway
Target(s)	Substance-P receptor	Target Info	Antagonist	[534708]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Measles
PANTHER Pathway	CCKR signaling map ST
Reactome	G alpha (q) signalling events
WikiPathways	SIDS Susceptibility Pathways
	Gastrin-CREB signalling pathway via PKC and MAPK
	Spinal Cord Injury
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 546834	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010524)
Ref 534708	The effects of SDZ NKT 343, a potent NK1 receptor antagonist, on cutaneous responses of primate spinothalamic tract neurones sensitized by intradermal capsaicin injection. Exp Brain Res. 1998 Aug;121(3):355-8.

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Drug Information