Drug Information

Drug General Information
Drug ID
D04RZD
Former ID
DAP001285
Drug Name
Interferon Alfa-2b, Recombinant
Synonyms
Alpharona (TN); Genferon (TN); Gerpferon (TN); Grippferon (TN); Infagel (TN); Intron A (TN); Kipferon (TN); Pegasys (TN); Pegintron (TN); Realderon (TN); Recolin (TN); Teva (TN); Viferon (TN)
Indication Hairy cell leukemia [ICD9: 202.4; ICD10:C91.4] Approved [536361]
Therapeutic Class
Anticancer Agents
Company
Schering-Plough
Formula
C860H1353N229O255S9
CAS Number
CAS 99210-65-8
Target and Pathway
Target(s) Interferon-alpha/beta receptor Target Info Binder [537218]
KEGG Pathway Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Osteoclast differentiation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
Hepatitis C
Hepatitis B
Measles
Influenza A
Herpes simplex infection
Reactome Interferon alpha/beta signaling
Regulation of IFNA signaling
WikiPathways Toll-like receptor signaling pathway
Interferon type I signaling pathways
Interferon alpha/beta signaling
Regulation of toll-like receptor signaling pathway
Osteoclast Signaling
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 537218Successful treatment of relapsed Philadelphia chromosome-positive acute lymphoblastic leukemia with T315I mutation after haplo-identical hematopoietic stem cell transplantation with donor lymphocyte transfusion and interferon-alpha-2b. Leuk Res. 2009 Aug;33(8):e111-3. Epub 2009 Apr 10.

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