Drug Information

Drug General Information
Drug ID
D04SBH
Former ID
DNC001531
Drug Name
Zamifenacin
Drug Type
Small molecular drug
Indication Urinary incontinence [ICD9: 788.3; ICD10:N39.3, N39.4, R32] Discontinued in Phase 3 [545544]
Structure
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2D MOL

3D MOL
Formula
C27H29NO3
Canonical SMILES
C1CC(CN(C1)CCC2=CC3=C(C=C2)OCO3)OC(C4=CC=CC=C4)C5=CC=CC<br />=C5
InChI
1S/C27H29NO3/c1-3-8-22(9-4-1)27(23-10-5-2-6-11-23)31-24-12-7-16-28(19-24)17-15-21-13-14-25-26(18-21)30-20-29-25/h1-6,8-11,13-14,18,24,27H,7,12,15-17,19-20H2/t24-/m1/s1
InChIKey
BDNFQGRSKSQXRI-XMMPIXPASA-N
CAS Number
CAS 127308-82-1
PubChem Compound ID
3086618
PubChem Substance ID
9472212, 14831354, 36416363, 52208958, 85788210, 103196823, 111695250, 124954237, 127499905, 134340695, 135236251, 137310662, 144210530, 176229895, 179149757, 198971048, 215781612, 223554823, 226650954
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M3 Target Info Antagonist [535150]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeleton
Insulin secretion
Salivary secretion
Gastric acid secretion
Pancreatic secretion
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
PathWhiz Pathway Gastric Acid Production
Reactome Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 545544Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003650)
Ref 535150Drug treatment options for irritable bowel syndrome: managing for success. Drugs Aging. 2001;18(3):201-11.

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