Drug General Information
Drug ID	D04SCQ
Former ID	DNC010216
Drug Name	4,4-Diphenylbutan-1-amine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530331]
Structure		Download 2D MOL 3D MOL
Formula	C16H19N
Canonical SMILES	C1=CC=C(C=C1)C(CCCN)C2=CC=CC=C2
InChI	1S/C16H19N/c17-13-7-12-16(14-8-3-1-4-9-14)15-10-5-2-6-11-15/h1-6,8-11,16H,7,12-13,17H2
InChIKey	MAAQGZFMFXQVOG-UHFFFAOYSA-N
PubChem Compound ID	3015863
Target and Pathway
Target(s)	Histamine H1 receptor	Target Info	Inhibitor	[530331]
	5-hydroxytryptamine 2A receptor	Target Info	Inhibitor	[530331]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
	Gap junction
	Serotonergic synapse
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	Histamine H1 receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
Reactome	Histamine receptors
	G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
	G alpha (q) signalling events
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	IL-4 Signaling Pathway
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	SIDS Susceptibility Pathways
	GPCR downstream signaling
	GPCRs, Other
References
Ref 530331	Bioorg Med Chem. 2009 Sep 15;17(18):6496-504. Epub 2009 Aug 13.Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity.
Ref 530331	Bioorg Med Chem. 2009 Sep 15;17(18):6496-504. Epub 2009 Aug 13.Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity.

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