Drug General Information
Drug ID	D04TNT
Former ID	DNCL002937
Drug Name	ABT-639
Drug Type	Small molecular drug
Indication	Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89]		Phase 2	[533259], [542694]
Structure		Download 2D MOL
Formula	C20H20ClF2N3O3S
InChIKey	AGPIHNZOZNKRGT-CYBMUJFWSA-N
PubChem Compound ID	46851313
PubChem Substance ID	99240370, 120890113, 223366054, 224413548, 226728676, 247990000
Target and Pathway
Target(s)	Voltage-dependent T-type calcium channel subunit alpha-1H	Target Info	Modulator	[533259]
KEGG Pathway	MAPK signaling pathway
	Calcium signaling pathway
	Circadian entrainment
PathWhiz Pathway	Muscle/Heart Contraction
Reactome	NCAM1 interactions
WikiPathways	Corticotropin-releasing hormone
	NCAM signaling for neurite out-growth
References
Ref 533259	Effects of a T-type calcium channel blocker, ABT-639, on spontaneous activity in C-nociceptors in patients with painful diabetic neuropathy: a randomized controlled trial. Pain. 2015 Nov;156(11):2175-83.
Ref 542694	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7721).
Ref 533259	Effects of a T-type calcium channel blocker, ABT-639, on spontaneous activity in C-nociceptors in patients with painful diabetic neuropathy: a randomized controlled trial. Pain. 2015 Nov;156(11):2175-83.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.