Drug General Information
Drug ID	D04UNQ
Former ID	DNC006932
Drug Name	4-(phenyldiazenyl)-1H-pyrazole-3,5-diamine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528490]
Structure		Download 2D MOL 3D MOL
Formula	C9H10N6
Canonical SMILES	C1=CC=C(C=C1)NN=C2C(=NN=C2N)N
InChI	1S/C9H10N6/c10-8-7(9(11)15-14-8)13-12-6-4-2-1-3-5-6/h1-5,12H,(H4,10,11,13,14,15)
InChIKey	OKZNBFAXFGTZRH-UHFFFAOYSA-N
PubChem Compound ID	5284904
Target and Pathway
Target(s)	Cyclin-A2	Target Info	Inhibitor	[528490]
	Cell division protein kinase 9	Target Info	Inhibitor	[528490]
KEGG Pathway	DNA replication
	Base excision repair
	Nucleotide excision repair
	Mismatch repair
	Cell cycle
	Hepatitis B
	HTLV-I infectionhsa05202:Transcriptional misregulation in cancer
NetPath Pathway	EGFR1 Signaling Pathway
PathWhiz Pathway	Nucleotide Excision Repair
Reactome	E2F mediated regulation of DNA replication
	G0 and Early G1
	Cdc20:Phospho-APC/C mediated degradation of Cyclin A
	Regulation of APC/C activators between G1/S and early anaphase
	SCF(Skp2)-mediated degradation of p27/p21
	Senescence-Associated Secretory Phenotype (SASP)
	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
	HDR through Homologous Recombination (HRR)
	Processing of DNA double-strand break ends
	Dual Incision in GG-NER
	Dual incision in TC-NER
	Gap-filling DNA repair synthesis and ligation in TC-NER
	G2 Phase
	Orc1 removal from chromatin
	G1/S-Specific Transcription
	Cyclin A/B1 associated events during G2/M transition
	Cyclin A:Cdk2-associated events at S phase entryR-HSA-2173796:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
WikiPathways	Senescence and Autophagy in Cancer
	Mismatch repair
	DNA Replication
	G1 to S cell cycle control
	EGF/EGFR Signaling Pathway
	S Phase
	Nifedipine Activity
	Primary Focal Segmental Glomerulosclerosis FSGS
	Retinoblastoma (RB) in Cancer
	Integrated Pancreatic Cancer Pathway
	Nucleotide Excision Repair
	Telomere Maintenance
	Synthesis of DNA
	Mitotic G1-G1/S phases
	Cell Cycle
	Base Excision RepairWP2795:Cardiac Hypertrophic Response
	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
	Host Interactions of HIV factors
	HIV Life Cycle
	IL-9 Signaling Pathway
	RNA Polymerase II Transcription
	MicroRNAs in cardiomyocyte hypertrophy
References
Ref 528490	J Med Chem. 2006 Nov 2;49(22):6500-9.4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects.
Ref 528490	J Med Chem. 2006 Nov 2;49(22):6500-9.4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects.

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