Drug General Information
Drug ID
D04UYT
Former ID
DIB004346
Drug Name
CBLB-612
Synonyms
Protectans; Recombinant flagellin proteins (injectable, radiation induced bone marrow deficiency), Cleveland BioLabs; CBLB-600 series (injectable, radiation sickness), Cleveland BioLabs
Indication Radiation sickness [ICD9: 990; ICD10:T66] Investigative [543472]
Company
Cleveland BioLabs Inc
Target and Pathway
Target(s) Toll-like receptor 2 Target Info Modulator [543472]
KEGG Pathway Phagosome
PI3K-Akt signaling pathway
Toll-like receptor signaling pathway
Legionellosis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Malaria
Toxoplasmosis
Amoebiasis
Tuberculosis
Hepatitis B
Measles
Herpes simplex infection
Proteoglycans in cancer
Inflammatory bowel disease (IBD)
Rheumatoid arthritis
NetPath Pathway IL4 Signaling Pathway
TCR Signaling Pathway
PANTHER Pathway Toll receptor signaling pathway
Pathway Interaction Database Endogenous TLR signaling
Reactome Beta defensins
MyD88:Mal cascade initiated on plasma membrane
Toll Like Receptor TLR6:TLR2 Cascade
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
WikiPathways Toll-like receptor signaling pathway
IL1 and megakaryotyces in obesity
Human Complement System
Toll-Like Receptors Cascades
MyD88:Mal cascade initiated on plasma membrane
Defensins
Regulation of toll-like receptor signaling pathway
References
Ref 543472(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1752).
Ref 543472(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1752).

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