Drug Information

Drug General Information
Drug ID
D04VCE
Former ID
DNC009431
Drug Name
TETRAHYDROQUINOLINE A
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530053]
Structure
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2D MOL

3D MOL
Formula
C26H20F9NO3
Canonical SMILES
C1CC2=C(C=CC=C2N(C1C3=CC(=CC=C3)OC(F)(F)F)CC(C(F)(F)F)O<br />)C4=CC(=CC=C4)OC(F)(F)F
InChI
1S/C26H20F9NO3/c27-24(28,29)23(37)14-36-21(16-5-2-7-18(13-16)39-26(33,34)35)11-10-20-19(8-3-9-22(20)36)15-4-1-6-17(12-15)38-25(30,31)32/h1-9,12-13,21,23,37H,10-11,14H2/t21-,23+/m1/s1
InChIKey
CMOJRCASVGGDKQ-GGAORHGYSA-N
PubChem Compound ID
44591717
Target and Pathway
Target(s) Cholesteryl ester transfer protein Target Info Inhibitor [530053]
PANTHER Pathway CCKR signaling map ST
Reactome LDL-mediated lipid transport
HDL-mediated lipid transport
WikiPathways Statin Pathway
Lipid digestion, mobilization, and transport
References
Ref 530053Bioorg Med Chem Lett. 2009 May 1;19(9):2456-60. Epub 2009 Mar 18.Design and synthesis of potent inhibitors of cholesteryl ester transfer protein (CETP) exploiting a 1,2,3,4-tetrahydroquinoline platform.
Ref 530053Bioorg Med Chem Lett. 2009 May 1;19(9):2456-60. Epub 2009 Mar 18.Design and synthesis of potent inhibitors of cholesteryl ester transfer protein (CETP) exploiting a 1,2,3,4-tetrahydroquinoline platform.

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