Drug Information

Drug General Information
Drug ID
D04VGL
Former ID
DIB018628
Drug Name
4P-PDOT
Synonyms
N-(4-phenyltetralin-2-yl)propanamide; 4P-PDOT; 4-phenyl-2-propionamidotetraline
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538835]
Structure
Download
2D MOL
Formula
C19H21NO
InChI
InChI=1S/C19H21NO/c1-2-19(21)20-16-12-15-10-6-7-11-17(15)18(13-16)14-8-4-3-5-9-14/h3-11,16,18H,2,12-13H2,1H3,(H,20,21)
InChIKey
RCYLUNPFECYGDW-UHFFFAOYSA-N
PubChem Compound ID
3976006
PubChem Substance ID
5837742, 7978598, 9425737, 14972827, 26752040, 35170562, 47359978, 48254048, 78922489, 85208923, 85787583, 91746235, 103206305, 104098288, 112535406, 126722905, 129111352, 134223236, 135649804, 135698302, 137048554, 162022760, 179293790, 224939215, 226437784, 241032561, 241182068, 241375176
Target and Pathway
Target(s) Melatonin receptor Target Info Antagonist [534706]
KEGG Pathway Neuroactive ligand-receptor interaction
Circadian entrainment
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 538835(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1358).
Ref 534706Selective MT2 melatonin receptor antagonists block melatonin-mediated phase advances of circadian rhythms. FASEB J. 1998 Sep;12(12):1211-20.

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