Drug General Information
Drug ID	D04VWL
Former ID	DIB006855
Drug Name	Cannabinoid 1 antagonists
Synonyms	Cannabinoid 1 antagonists (obesity); Cannabinoid 1 antagonists (obesity), Gedeon Richter
Indication	Obesity [ICD9: 278; ICD10:E66]		Investigative	[552049]
Company	Gedeon Richter Ltd
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1cccc2c1N(C(c1n2ccc1)c1ccc(cc1)Cl)C(=O)CN(C(=O)C(C)Cl)<br />CCCC
Target and Pathway
Target(s)	Cannabinoid receptor 1	Target Info	Antagonist	[543877]
KEGG Pathway	Rap1 signaling pathway
	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
PANTHER Pathway	Endogenous cannabinoid signaling
Pathway Interaction Database	N-cadherin signaling events
Reactome	Class A/1 (Rhodopsin-like receptors)
	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Small Ligand GPCRs
	BDNF signaling pathway
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 552049	Chemical and biological investigation of cyclopropyl containing diaryl-pyrazole-3-carboxamides as novel and potent cannabinoid type 1 receptor antagonists. J Med Chem. 2009 Jul 23;52(14):4329-37
Ref 543877	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 56).

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