Drug Information

Drug General Information
Drug ID
D04WQJ
Former ID
DIB013777
Drug Name
AMG-181
Synonyms
Inflammatory bowel disease therapeutics, Amgen
Drug Type
Antibody
Indication Crohn's disease [ICD9: 555; ICD10:K50] Phase 2 [524078]
Company
Amgen; astrazeneca
Target and Pathway
Target(s) Integrin beta-7 Target Info [532239]
KEGG Pathway PI3K-Akt signaling pathway
Focal adhesion
ECM-receptor interaction
Cell adhesion molecules (CAMs)
Intestinal immune network for IgA production
Regulation of actin cytoskeleton
Transcriptional misregulation in cancer
Hypertrophic cardiomyopathy (HCM)
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Dilated cardiomyopathy
NetPath Pathway IL2 Signaling Pathway
Wnt Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Integrin signalling pathway
Pathway Interaction Database Integrin family cell surface interactions
AlphaE beta7 integrin cell surface interactions
E-cadherin signaling in the nascent adherens junction
a4b7 Integrin signaling
Beta5 beta6 beta7 and beta8 integrin cell surface interactions
Reactome Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Integrin cell surface interactions
WikiPathways Focal Adhesion
Arrhythmogenic Right Ventricular Cardiomyopathy
Integrin-mediated Cell Adhesion
Integrin cell surface interactions
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
References
Ref 524078ClinicalTrials.gov (NCT01696396) AMG 181 in Subjects With Moderate to Severe Crohn's Disease. U.S. National Institutes of Health.
Ref 532239Pharmacology of AMG 181, a human anti-alpha4 beta7 antibody that specifically alters trafficking of gut-homing T cells. Br J Pharmacol. 2013 May;169(1):51-68.

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