Drug Information

Drug General Information
Drug ID
D04XEG
Former ID
DAP000946
Drug Name
Fenoterol
Synonyms
Berotec; Berotek; Fenoterolum; Phenoterol; TH 1165; TH 1165A; Berotec (TN); Fenoterolum [INN-Latin]; P-Hydroxyphenylorciprenaline; Th-1165a; Fenoterol (USAN/INN); Fenoterol [USAN:BAN:INN]; P-Hydroxyphenyl-orciprenaline; 1-(3,5-Dihydroxyphenyl)-1-hydroxy-2-((4-hydroxyphenyl)isopropylamino)ethane; 1-(p-Hydroxyphenyl)-2-((beta-hydroxy-beta-(3',5'-dihydroxyphenyl))ethyl)aminopropane; 3,5-Dihydroxy-alpha-(((p-hydroxy-alpha-methylphenethyl)amino)methyl)benzyl alcohol; 5-(1-hydroxy-2-{[1-(4-hydroxyphenyl)propan-2-yl]amino}ethyl)benzene-1,3-diol; 5-(1-hydroxy-2-{[2-(4-hydroxyphenyl)-1-methylethyl]amino}ethyl)benzene-1,3-diol; 5-[1-hydroxy-2-[1-(4-hydroxyphenyl)propan-2-ylamino]ethyl]benzene-1,3-diol; 5-{1-Hydroxy-2-[2-(4-hydroxy-phenyl)-1-methyl-ethylamino]-ethyl}-benzene-1,3-diol
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Approved [536567], [540946]
Therapeutic Class
Bronchodilator Agents
Company
Boehriger Ingelheim
Structure
Download
2D MOL

3D MOL
Formula
C17H21NO4
InChI
InChI=1S/C17H21NO4/c1-11(6-12-2-4-14(19)5-3-12)18-10-17(22)13-7-15(20)9-16(21)8-13/h2-5,7-9,11,17-22H,6,10H2,1H3
InChIKey
LSLYOANBFKQKPT-UHFFFAOYSA-N
CAS Number
CAS 13392-18-2
PubChem Compound ID
3343
PubChem Substance ID
3139843, 5309237, 8152125, 11335580, 11360819, 11364140, 11366702, 11369264, 11371989, 11374645, 11377426, 11461791, 11466310, 11467430, 11485112, 11486139, 11489204, 11490730, 11492828, 11495060, 14898535, 29222478, 46509099, 47206103, 47291071, 47588932, 47736409, 48035038, 48184935, 48334419, 48334420, 48416005, 49698910, 49892796, 50111072, 50399113, 53787631, 57321740, 85209078, 85348787, 85788457, 90340690, 92712692, 103209027, 103850832, 104022469, 104094325, 104303233, 117616342, 124749797
SuperDrug ATC ID
G02CA03; R03AC04; R03CC04
SuperDrug CAS ID
cas=013392182
Target and Pathway
Target(s) Beta-2 adrenergic receptor Target Info Agonist [535311], [537192]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Adrenergic signaling in cardiomyocytes
Salivary secretion
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta2 adrenergic receptor signaling pathway
Pathway Interaction Database Arf6 trafficking events
Arf6 signaling events
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 536567Acute clenbuterol overdose resulting in supraventricular tachycardia and atrial fibrillation. J Med Toxicol. 2007 Jun;3(2):56-60.
Ref 540946(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 557).
Ref 535311Effect of fenoterol-induced constitutive beta(2)-adrenoceptor activity on contractile receptor function in airway smooth muscle. Eur J Pharmacol. 2001 Nov 23;431(3):353-9.
Ref 537192Functional alpha1- and beta2-adrenergic receptors in human osteoblasts. J Cell Physiol. 2009 Jul;220(1):267-75.

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