Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D04YXL
|
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| Former ID |
DIB016133
|
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| Drug Name |
PEGylated IFN beta 1-a
|
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| Synonyms |
BIIB-017; PEG-Avonex; PEGylated IFN beta 1-a (multiple sclerosis); PEGylated IFN beta 1-a (multiple sclerosis), Biogen Idec; PEGylated interferon beta 1-a (multiple sclerosis), Biogen Idec
|
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| Company |
Biogen idec
|
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| Target and Pathway | |||||
| Target(s) | Interferon beta ligand | Target Info | Modulator | [532764] | |
| KEGG Pathway | Cytokine-cytokine receptor interaction | ||||
| PI3K-Akt signaling pathway | |||||
| Osteoclast differentiation | |||||
| Toll-like receptor signaling pathway | |||||
| RIG-I-like receptor signaling pathway | |||||
| Cytosolic DNA-sensing pathway | |||||
| Jak-STAT signaling pathway | |||||
| Natural killer cell mediated cytotoxicity | |||||
| Chagas disease (American trypanosomiasis) | |||||
| Tuberculosis | |||||
| Hepatitis C | |||||
| Hepatitis B | |||||
| Measles | |||||
| Influenza A | |||||
| Herpes simplex infection | |||||
| NetPath Pathway | TNFalpha Signaling Pathway | ||||
| PANTHER Pathway | Toll receptor signaling pathway | ||||
| Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | ||||
| WikiPathways | Toll-like receptor signaling pathway | ||||
| Type II interferon signaling (IFNG) | |||||
| Senescence and Autophagy in Cancer | |||||
| Cytokines and Inflammatory Response | |||||
| EBV LMP1 signaling | |||||
| RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | |||||
| Interferon alpha/beta signaling | |||||
| Regulation of toll-like receptor signaling pathway | |||||
| Osteoclast Signaling | |||||
| References | |||||
| Ref 524908 | ClinicalTrials.gov (NCT02234869) Transition to Peginterferon Beta-1a (BIIB017) From Subcutaneous Interferon Therapy. U.S. National Institutes of Health. | ||||
| Ref 532764 | Pegylated interferon beta-1a for relapsing-remitting multiple sclerosis (ADVANCE): a randomised, phase 3, double-blind study. Lancet Neurol. 2014 Jul;13(7):657-65. | ||||
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