Drug General Information
Drug ID	D04ZEP
Former ID	DIB007210
Drug Name	A-849531
Synonyms	A-849531
Indication	Metabolic disorders [ICD9: 270-279; ICD10:E70-E89]		Investigative	[543704]
Company	Abbott Laboratories
Structure		Download 2D MOL 3D MOL
Canonical SMILES	FC(F)(c1ccc(C(C)(C)C(=O)N[C@@H]2[C@@H]3C[C@@H]4C[C@H]2C<br />[C@](C3)(C4)C(=O)N)cc1)F
Target and Pathway
Target(s)	Corticosteroid 11-beta-dehydrogenase, isozyme 1	Target Info	Inhibitor	[543704]
KEGG Pathway	Steroid hormone biosynthesis
	Metabolism of xenobiotics by cytochrome P450
	Metabolic pathways
	Chemical carcinogenesis
NetPath Pathway	IL1 Signaling Pathway
	FSH Signaling Pathway
PathWhiz Pathway	Steroidogenesis
Reactome	Glucocorticoid biosynthesis
WikiPathways	Prostaglandin Synthesis and Regulation
	Metabolism of steroid hormones and vitamin D
	Glucocorticoid & Mineralcorticoid Metabolism
References
Ref 543704	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2763).
Ref 543704	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2763).

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