Drug Information

Drug General Information
Drug ID
D04ZNL
Former ID
DIB007391
Drug Name
RG-7234
Synonyms
R-7234; RO-5027838; 11-beta HSD 2 (type 2 diabetes), Roche; 11-beta hydroxysteroid dehydrogenase inhibitor 2 (type 2 diabetes), Roche
Indication Type 2 diabetes [ICD9: 250; ICD10:E11] Phase 2 [522547]
Company
F Hoffmann-La Roche Ltd
Target and Pathway
Target(s) Corticosteroid 11-beta-dehydrogenase, isozyme 2 Target Info Inhibitor [551800]
KEGG Pathway Steroid hormone biosynthesis
Aldosterone-regulated sodium reabsorption
NetPath Pathway EGFR1 Signaling Pathway
PathWhiz Pathway Steroidogenesis
Reactome Glucocorticoid biosynthesis
WikiPathways Prostaglandin Synthesis and Regulation
Glucocorticoid & Mineralcorticoid Metabolism
References
Ref 522547ClinicalTrials.gov (NCT00823680) A Study of RO5093151 and RO5027838 in Patients With Type 2 Diabetes Mellitus on a Stable Dose of Metformin. U.S. National Institutes of Health.
Ref 551800New Therapeutic Strategies for Type 2 Diabetes: Small Molecule Approaches. 2012. Chapter 5. Page(131).

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