Drug Information

Drug General Information
Drug ID
D05AZW
Former ID
DNC010484
Drug Name
Alstiphyllanine E
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530756]
Structure
Download
2D MOL

3D MOL
Formula
C30H32N2O7
Canonical SMILES
CC=C1CN2C3CC1C(C45C3(NC6=CC=CC=C64)OC2C5)(COC(=O)C7=CC(<br />=C(C=C7)OC)OC)C(=O)OC
InChI
1S/C30H32N2O7/c1-5-17-15-32-24-13-20(17)28(27(34)37-4,16-38-26(33)18-10-11-22(35-2)23(12-18)36-3)29-14-25(32)39-30(24,29)31-21-9-7-6-8-19(21)29/h5-12,20,24-25,31H,13-16H2,1-4H3/b17-5-/t20-,24-,25-,28-,29-,30-/m0/s1
InChIKey
NPAPHJSGCRCHBM-UMLFCLJTSA-N
PubChem Compound ID
46229071
Target and Pathway
Target(s) Sodium/glucose cotransporter 1 Target Info Inhibitor [530756]
mRNA of sodium-glucosetransporter-2 Target Info Inhibitor [530756]
KEGG Pathway Carbohydrate digestion and absorption
Bile secretion
Mineral absorption
PathWhiz Pathway Lactose Degradation
Trehalose Degradation
Reactome Hexose transport
Na+-dependent glucose transporters
Inositol transportersR-HSA-189200:Hexose transport
Inositol transporters
WikiPathways NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Metabolism of carbohydratesWP2884:NRF2 pathway
References
Ref 530756Bioorg Med Chem. 2010 Mar 15;18(6):2152-8. Epub 2010 Feb 6.Alstiphyllanines E-H, picraline and ajmaline-type alkaloids from Alstonia macrophylla inhibiting sodium glucose cotransporter.
Ref 530756Bioorg Med Chem. 2010 Mar 15;18(6):2152-8. Epub 2010 Feb 6.Alstiphyllanines E-H, picraline and ajmaline-type alkaloids from Alstonia macrophylla inhibiting sodium glucose cotransporter.

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