Drug General Information
Drug ID	D05DUX
Former ID	DNC007342
Drug Name	Petrosaspongiolide M
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528771]
Structure		Download 2D MOL 3D MOL
Formula	C27H40O6
PubChem Compound ID	17748437
Target and Pathway
Target(s)	Phospholipase A2	Target Info	Inhibitor	[528771]
BioCyc Pathway	Phospholipases
KEGG Pathway	Glycerophospholipid metabolism
	Ether lipid metabolism
	Arachidonic acid metabolism
	Linoleic acid metabolism
	alpha-Linolenic acid metabolism
	Metabolic pathways
	Ras signaling pathway
	Vascular smooth muscle contraction
	Pancreatic secretion
	Fat digestion and absorption
Pathway Interaction Database	Fc-epsilon receptor I signaling in mast cells
Reactome	Acyl chain remodelling of PC
	Acyl chain remodelling of PE
	Acyl chain remodelling of PI
WikiPathways	Glycerophospholipid biosynthesis
References
Ref 528771	J Med Chem. 2007 May 3;50(9):2176-84. Epub 2007 Apr 4.Synthesis and pharmacological evaluation of a selected library of new potential anti-inflammatory agents bearing the gamma-hydroxybutenolide scaffold: a new class of inhibitors of prostanoid production through the selective modulation of microsomal prostaglandin E synthase-1 expression.
Ref 528771	J Med Chem. 2007 May 3;50(9):2176-84. Epub 2007 Apr 4.Synthesis and pharmacological evaluation of a selected library of new potential anti-inflammatory agents bearing the gamma-hydroxybutenolide scaffold: a new class of inhibitors of prostanoid production through the selective modulation of microsomal prostaglandin E synthase-1 expression.

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