Drug General Information
Drug ID
D05EKM
Former ID
DIB002600
Drug Name
FR-121196
Drug Type
Small molecular drug
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Terminated [544870]
Company
Fujisawa Pharmaceutical Co Ltd
Structure
Download
2D MOL

3D MOL

Formula
C12H16FN3O3S
Canonical SMILES
S(=O)(=O)(NN1CCN(C(=O)C)CC1)c1ccc(cc1)F
CAS Number
CAS 133920-65-7
PubChem Compound ID
Target and Pathway
Target(s) Somatostatin receptor type 4 Target Info Modulator [533791]
Somatostatin receptor type 2 Target Info Modulator [533791]
Somatostatin receptor type 3 Target Info Modulator [530618], [532210]
Somatostatin receptor type 5 Target Info Modulator [533791]
Somatostatin receptor 1 Target Info Modulator [530618], [532210]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04024:cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretionhsa04080:Neuroactive ligand-receptor interactionhsa04024:cAMP signaling pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
PathWhiz Pathway Gastric Acid Production
Reactome Peptide ligand-binding receptors
G alpha (i) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signalingWP706:SIDS Susceptibility Pathways
GPCR downstream signaling
GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
References
Ref 544870Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001380)
Ref 530618Mol Endocrinol. 2010 Feb;24(2):436-46. Epub 2010 Jan 5.Pasireotide and octreotide stimulate distinct patterns of sst2A somatostatin receptor phosphorylation.
Ref 532210Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
Ref 533791Role of somatostatin in the augmentation of hippocampal long-term potentiation by FR121196, a putative cognitive enhancer. Eur J Pharmacol. 1993 Sep 7;241(1):27-34.

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