Drug Information

Drug General Information
Drug ID
D05EPU
Former ID
DNC001536
Drug Name
ZD7114
Drug Type
Small molecular drug
Indication Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1] Phase 1 [525938]
Structure
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2D MOL

3D MOL
Formula
C22H30N2O6
Canonical SMILES
COCCNC(=O)COC1=CC=C(C=C1)OCCNCC(COC2=CC=CC=C2)O
InChI
1S/C22H30N2O6/c1-27-13-12-24-22(26)17-30-21-9-7-20(8-10-21)28-14-11-23-15-18(25)16-29-19-5-3-2-4-6-19/h2-10,18,23,25H,11-17H2,1H3,(H,24,26)/t18-/m0/s1
InChIKey
RVMBDLSFFNKKLG-SFHVURJKSA-N
CAS Number
CAS 129689-30-1
PubChem Compound ID
121877
PubChem Substance ID
10239844, 14831526, 26756517, 29302374, 49859707, 57339822, 75116991, 81065622, 104414487, 129187709, 131273851, 135077386, 184538685, 223554800, 226644813
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Agonist [534855]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 525938Effects of the two beta3-agonists, ZD7114 and ZD2079 on 24 hour energy expenditure and respiratory quotient in obese subjects. Int J Obes Relat Metab Disord. 2000 Dec;24(12):1553-60.
Ref 534855Urinary tract toxicity in rats following administration of beta 3-adrenoceptor agonists. Toxicol Pathol. 1999 Mar-Apr;27(2):165-70.

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