Drug Information

Drug General Information
Drug ID
D05FFB
Former ID
DNC005818
Drug Name
5,11-Dimethyl-6H-pyrido[4,3-b]carbazol-9-ol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527769]
Structure
Download
2D MOL

3D MOL
Formula
C17H14N2O
Canonical SMILES
CC1=C2C(=C(C3=C1C=CN=C3)C)C4=C(N2)C=CC(=C4)O
InChI
1S/C17H14N2O/c1-9-14-8-18-6-5-12(14)10(2)17-16(9)13-7-11(20)3-4-15(13)19-17/h3-8,19-20H,1-2H3
InChIKey
QZTWUDDGLIDXSE-UHFFFAOYSA-N
PubChem Compound ID
91643
Target and Pathway
Target(s) Alpha platelet-derived growth factor receptor Target Info Inhibitor [527769]
FGF-3 receptor Target Info Inhibitor [527769]
Mast/stem cell growth factor receptor Target Info Inhibitor [527769]
KEGG Pathway MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
Cytokine-cytokine receptor interaction
Endocytosis
PI3K-Akt signaling pathway
Focal adhesion
Gap junction
Regulation of actin cytoskeleton
HTLV-I infection
Pathways in cancer
MicroRNAs in cancer
Glioma
Prostate cancer
Melanoma
Central carbon metabolism in cancer
Choline metabolism in cancerhsa04010:MAPK signaling pathway
Signaling pathways regulating pluripotency of stem cells
Bladder cancer
Central carbon metabolism in cancerhsa04014:Ras signaling pathway
Hematopoietic cell lineage
Melanogenesis
Acute myeloid leukemia
NetPath Pathway TGF_beta_Receptor Signaling PathwayNetPath_15:IL3 Signaling Pathway
IL4 Signaling Pathway
KitReceptor Signaling Pathway
PANTHER Pathway Angiogenesis
PDGF signaling pathwayP00021:FGF signaling pathway
Pathway Interaction Database ATF-2 transcription factor network
PDGFR-alpha signaling pathway
PDGF receptor signaling networkcmyb_pathway:C-MYB transcription factor network
Signaling events mediated by Stem cell factor receptor (c-Kit)
Reactome PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascadeR-HSA-2033514:FGFR3 mutant receptor activationR-HSA-1257604:PIP3 activates AKT signaling
Regulation of KIT signaling
RAF/MAP kinase cascade
WikiPathways Regulation of Actin Cytoskeleton
Osteoblast Signaling
Focal Adhesion
Hair Follicle Development: Organogenesis (Part 2 of 3)
PIP3 activates AKT signaling
Cardiac Progenitor Differentiation
Integrated Pancreatic Cancer Pathway
Allograft Rejection
Signaling Pathways in Glioblastoma
Signaling by PDGF
AngiogenesisWP51:Regulation of Actin Cytoskeleton
Endochondral Ossification
Bladder Cancer
Neural Crest Differentiation
Signaling by FGFRWP304:Kit receptor signaling pathway
Differentiation Pathway
Signaling by SCF-KIT
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
References
Ref 527769J Med Chem. 2005 Oct 6;48(20):6194-201.Molecular modeling of wild-type and D816V c-Kit inhibition based on ATP-competitive binding of ellipticine derivatives to tyrosine kinases.
Ref 527769J Med Chem. 2005 Oct 6;48(20):6194-201.Molecular modeling of wild-type and D816V c-Kit inhibition based on ATP-competitive binding of ellipticine derivatives to tyrosine kinases.

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