Drug Information

Drug General Information
Drug ID
D05FGR
Former ID
DNC006444
Drug Name
R-flurbiprofen
Drug Type
Small molecular drug
Indication Discovery agent Phase 2 [521532], [542364]
Structure
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2D MOL

3D MOL
Formula
C15H13FO2
InChI
InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)/t10-/m1/s1
InChIKey
SYTBZMRGLBWNTM-SNVBAGLBSA-N
PubChem Compound ID
92337
PubChem Substance ID
520769, 803799, 841054, 10225348, 11112562, 11114208, 12015300, 14749662, 15196534, 24775785, 24878847, 44423182, 50100872, 57335240, 74982718, 91699354, 96025693, 99206222, 103459354, 104058528, 104407155, 119526881, 124757425, 124883374, 124883378, 124883379, 125164229, 126531730, 126687010, 129308098, 131316938, 134343649, 135049354, 135659612, 137001902, 152030647, 162037701, 163126955, 175267390, 175269361, 175426967, 176484699, 178103912, 184531631, 223672082, 224564111, 226414056, 241090976, 249773516, 251890381
Target and Pathway
Target(s) Gamma-secretase Target Info Inhibitor [528008]
Beta-secretase Target Info Inhibitor [528008]
Presenilin 2 Target Info Inhibitor [528008]
Presenilin 1 Target Info Inhibitor [528008]
KEGG Pathway Notch signaling pathway
Alzheimer's diseasehsa04330:Notch signaling pathway
Neurotrophin signaling pathway
Alzheimer's diseasehsa04310:Wnt signaling pathway
Alzheimer's disease
NetPath Pathway Notch Signaling Pathway
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Alzheimer disease-presenilin pathway
Notch signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
Notch signaling pathway
Pathway Interaction Database Notch signaling pathway
Presenilin action in Notch and Wnt signaling
p75(NTR)-mediated signaling
Syndecan-3-mediated signaling eventslkb1_pathway:LKB1 signaling eventsnotch_pathway:Notch signaling pathway
Syndecan-3-mediated signaling events
Reactome Nuclear signaling by ERBB4
Regulated proteolysis of p75NTR
NRIF signals cell death from the nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
EPH-ephrin mediated repulsion of cellsR-HSA-1251985:Nuclear signaling by ERBB4
EPH-ephrin mediated repulsion of cellsR-HSA-1474228:Degradation of the extracellular matrix
WikiPathways Notch Signaling Pathway
Signaling by ERBB4
Signaling by NOTCH3
Signaling by NOTCH4
Signaling by NOTCH1
Signaling by NOTCH2
Notch Signaling Pathway
Signalling by NGFWP61:Notch Signaling Pathway
Alzheimers Disease
References
Ref 521532ClinicalTrials.gov (NCT00045123) R-Flurbiprofen in Treating Patients With Localized Prostate Cancer at Risk of Recurrence. U.S. National Institutes of Health.
Ref 542364(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7340).
Ref 528008Bioorg Med Chem Lett. 2006 Apr 15;16(8):2219-23. Epub 2006 Feb 7.The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent.

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