Drug Information

Drug General Information
Drug ID
D05FRX
Former ID
DNC005482
Drug Name
(3,5-Dibromo-4-hexyloxy-phenyl)-acetic acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527532]
Structure
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2D MOL

3D MOL
Formula
C14H18Br2O3
Canonical SMILES
CCCCCCOC1=C(C=C(C=C1Br)CC(=O)O)Br
InChI
1S/C14H18Br2O3/c1-2-3-4-5-6-19-14-11(15)7-10(8-12(14)16)9-13(17)18/h7-8H,2-6,9H2,1H3,(H,17,18)
InChIKey
VJKVJESSSPWLJY-UHFFFAOYSA-N
PubChem Compound ID
11153607
Target and Pathway
Target(s) Thyroid hormone receptor beta-1 Target Info Inhibitor [527532]
Thyroid hormone receptor alpha Target Info Inhibitor [527532]
KEGG Pathway Neuroactive ligand-receptor interaction
Thyroid hormone signaling pathwayhsa04080:Neuroactive ligand-receptor interaction
Thyroid hormone signaling pathway
Pathway Interaction Database RXR and RAR heterodimerization with other nuclear receptorrxr_vdr_pathway:RXR and RAR heterodimerization with other nuclear receptor
Reactome Nuclear Receptor transcription pathwayR-HSA-383280:Nuclear Receptor transcription pathway
WikiPathways SIDS Susceptibility Pathways
Hematopoietic Stem Cell Differentiation
Nuclear ReceptorsWP474:Endochondral Ossification
Nuclear Receptors
References
Ref 527532J Med Chem. 2005 May 5;48(9):3114-7.Thyroid receptor ligands. 3. Design and synthesis of 3,5-dihalo-4-alkoxyphenylalkanoic acids as indirect antagonists of the thyroid hormone receptor.
Ref 527532J Med Chem. 2005 May 5;48(9):3114-7.Thyroid receptor ligands. 3. Design and synthesis of 3,5-dihalo-4-alkoxyphenylalkanoic acids as indirect antagonists of the thyroid hormone receptor.

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