Drug Information

Drug General Information
Drug ID
D05FYA
Former ID
DNC001435
Drug Name
Thioperamide
Drug Type
Small molecular drug
Indication Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10:F01-F07, F04, F05, R41.3] Terminated [538782], [545719]
Structure
Download
2D MOL

3D MOL
Formula
C15H24N4S
InChI
InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20)
InChIKey
QKDDJDBFONZGBW-UHFFFAOYSA-N
CAS Number
CAS 106243-16-7
PubChem Compound ID
3035905
PubChem Substance ID
5646740, 5849660, 11111845, 11113618, 14922585, 14922586, 24536774, 26751818, 36104185, 47721703, 49846728, 50015455, 50104511, 51054761, 57353295, 85083113, 85209332, 85788104, 90341317, 96024154, 99206112, 103566780, 103941424, 111640044, 124750325, 124881519, 124881520, 124881521, 126591031, 129034527, 134340541, 134340617, 135143800, 135651258, 135698493, 135756358, 137185856, 142231014, 142667105, 179149541, 179235817, 184581023, 198982124, 223446365, 228362787, 241181796, 241377426, 249617185, 250134232
Target and Pathway
Target(s) Histamine H3 receptor Target Info Antagonist [534934], [536039]
Histamine H4 receptor Target Info Antagonist [536039], [536681], [536849]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
Reactome Histamine receptors
G alpha (i) signalling eventsR-HSA-390650:Histamine receptors
G alpha (i) signalling events
WikiPathways Monoamine Transport
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP1825:GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 538782(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1267).
Ref 545719Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004362)
Ref 534934Combined histamine H1 and H3 receptor blockade produces nasal decongestion in an experimental model of nasal congestion. Am J Rhinol. 1999 Sep-Oct;13(5):391-9.
Ref 536039The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20.
Ref 536681Role of histamine H3 and H4 receptors in mechanical hyperalgesia following peripheral nerve injury. Neuroimmunomodulation. 2007;14(6):317-25. Epub 2008 Apr 10.
Ref 536849Role of histamine in short- and long-term effects of methamphetamine on the developing mouse brain. J Neurochem. 2008 Nov;107(4):976-86. Epub 2008 Sep 11.

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