Drug Information

Drug General Information
Drug ID
D05GQH
Former ID
DIB010077
Drug Name
ADX-88178
Synonyms
ADX-88178; MGluR4 positive modulators, Addex/Merck; MGluR4 PAM modulators (oral, Parkinson's disease/anxiety); MGluR4 PAM modulators (oral, Parkinson's disease/anxiety), Addex/Merck & Co
Drug Type
Small molecular drug
Indication Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] Investigative [541407]
Company
Addex Pharmaceuticals SA
Structure
Download
2D MOL
Formula
C12H12N6S
InChI
InChI=1S/C12H12N6S/c1-7-3-4-13-11(16-7)18-12-17-10(8(2)19-12)9-5-14-15-6-9/h3-6H,1-2H3,(H,14,15)(H,13,16,17,18)
InChIKey
MIQNXKWDQRNHAU-UHFFFAOYSA-N
PubChem Compound ID
46836872
PubChem Substance ID
99220043, 120879102, 135567793, 178102859, 202543576, 226701145
Target and Pathway
Target(s) Metabotropic glutamate receptor 4 Target Info Modulator [543749]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
Taste transduction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signaling
References
Ref 541407(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6238).
Ref 543749(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 292).

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