Drug General Information
Drug ID	D05HOS
Former ID	DNC002837
Drug Name	Hydroxyaminovaline
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[551393]
Structure		Download 2D MOL 3D MOL
Formula	C5H12N2O2
Canonical SMILES	CC(C)C(C(=O)NO)N
InChI	1S/C5H12N2O2/c1-3(2)4(6)5(8)7-9/h3-4,9H,6H2,1-2H3,(H,7,8)/t4-/m1/s1
InChIKey	USSBBYRBOWZYSB-SCSAIBSYSA-N
PubChem Compound ID	444599
PubChem Substance ID	838552, 7888071, 26703454, 36887565, 46508565, 51762563, 104632470, 129415060, 132631049, 137185103, 160965872, 162692513, 228616832
Target and Pathway
Target(s)	Collagenase 3	Target Info	Inhibitor	[551393]
	Stromelysin-1	Target Info	Inhibitor	[551393]
KEGG Pathway	TNF signaling pathway
	Transcriptional misregulation in cancer
	Rheumatoid arthritis
NetPath Pathway	IL1 Signaling PathwayNetPath_13:IL1 Signaling Pathway
	IL4 Signaling Pathway
PANTHER Pathway	Alzheimer disease-presenilin pathway
	Plasminogen activating cascadeP00050:Plasminogen activating cascade
	CCKR signaling map ST
Pathway Interaction Database	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signalingajdiss_2pathway:Posttranslational regulation of adherens junction stability and dissassembly
	p75(NTR)-mediated signaling
	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome	Collagen degradation
	Degradation of the extracellular matrix
	Activation of Matrix Metalloproteinases
	Assembly of collagen fibrils and other multimeric structuresR-HSA-1442490:Collagen degradation
	Assembly of collagen fibrils and other multimeric structures
	EGFR Transactivation by Gastrin
WikiPathways	Endochondral Ossification
	Activation of Matrix Metalloproteinases
	Oncostatin M Signaling Pathway
	AGE/RAGE pathway
	Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
	Gastrin-CREB signalling pathway via PKC and MAPK
	Matrix Metalloproteinases
References
Ref 551393	How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Ref 551393	How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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