Drug Information

Drug General Information
Drug ID
D05HZJ
Former ID
DIB009088
Drug Name
GPC-3298306
Synonyms
GPC3 peptide vaccine (hepatocellular carcinoma), Japanese National Cancer Center
Drug Type
Vaccine
Indication Hepatocellular carcinoma [ICD9: 155; ICD10:C22.0] Phase 2 [533301]
Company
Japanese National Cancer Center
Structure
Download
2D MOL

3D MOL
Canonical SMILES
N([C@H](C(=O)O)C(C)C)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@<br />@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O<br />)[C@@H](N)Cc1ccccc1)C(C)C)CCC(=O)O)Cc1ccccc1)Cc1ccccc1)<br />[C@H](O)C)CC(=O)O
Target and Pathway
Target(s) Glypican-3 Target Info [529782]
KEGG Pathway Proteoglycans in cancer
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Glypican pathway
Glypican 3 network
Reactome A tetrasaccharide linker sequence is required for GAG synthesis
HS-GAG degradation
Retinoid metabolism and transport
WikiPathways Visual phototransduction
References
Ref 533301Glypican-3 is a biomarker and a therapeutic target of hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int. 2015 Aug;14(4):361-6.
Ref 529782Usefulness of a novel oncofetal antigen, glypican-3, for diagnosis and immunotherapy of hepatocellular carcinoma. Nihon Rinsho Meneki Gakkai Kaishi. 2008 Oct;31(5):383-91.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.