Drug Information

Drug General Information
Drug ID
D05IHU
Former ID
DIB002792
Drug Name
Tetrahydrozoline
Synonyms
Tyzine
Drug Type
Small molecular drug
Indication Ocular disease [ICD10:H00-H59] Approved [529302]
Company
Fougera Pharmaceuticals Inc
Structure
Download
2D MOL

3D MOL
Formula
C13H17ClN2
Canonical SMILES
C1(c2c(CCC1)cccc2)C1=NCCN1
PubChem Compound ID
10648
Target and Pathway
Target(s) Alpha-2C adrenergic receptor Target Info Modulator [529302], [551871]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolism
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
References
Ref 529302Prolonged cardiovascular effects after unintentional ingestion of tetrahydrozoline. Clin Toxicol (Phila). 2008 Feb;46(2):171-2.
Ref 529302Prolonged cardiovascular effects after unintentional ingestion of tetrahydrozoline. Clin Toxicol (Phila). 2008 Feb;46(2):171-2.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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