Drug Information

Drug General Information
Drug ID
D05IPF
Former ID
DNCL003355
Drug Name
Kombiglyze XR/Komboglyze FDC
Drug Type
Small molecular drug
Indication Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1] Approved [550298]
Company
AstraZeneca
Structure
Download
2D MOL

3D MOL
Formula
C22H36N8O2
Canonical SMILES
CN(C)C(=N)N=C(N)N.C1C2CC2N(C1C#N)C(=O)C(C34CC5CC(C3)CC(<br />C5)(C4)O)N
InChI
1S/C18H25N3O2.C4H11N5/c19-8-13-2-12-3-14(12)21(13)16(22)15(20)17-4-10-1-11(5-17)7-18(23,6-10)9-17;1-9(2)4(7)8-3(5)6/h10-15,23H,1-7,9,20H2;1-2H3,(H5,5,6,7,8)/t10?,11?,12?,13-,14-,15+,17?,18?;/m1./s1
InChIKey
QUKZWYNGKYRRKE-RIKNOMPASA-N
PubChem Compound ID
56842229
PubChem Substance ID
135264783
Target and Pathway
Target(s) Dipeptidyl peptidase IV Target Info Modulator [543447]
KEGG Pathway Protein digestion and absorption
NetPath Pathway IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
References
Ref 550298KOMBIGLYZE? XR tablets approved in the US for the treatment of type 2 diabetes mellitus in adults
Ref 543447(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1612).

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