Drug General Information
Drug ID
D05LCX
Former ID
DIB012151
Drug Name
A-70276
Synonyms
A-71134
Indication Gastrointestinal disease [ICD10:K00-K93] Terminated [545481]
Company
Abbott Laboratories
Structure
Download
2D MOL

3D MOL

Canonical SMILES
n1c2c(c(cc1C(=O)N[C@@H](C(=O)N(CCCCC)CCCCC)Cc1c[nH]c3c1<br />cccc3)O)cccc2O
CAS Number
CAS 127387-81-9
Target and Pathway
Target(s) Cholecystokinin receptor type A Target Info Modulator [528964]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Insulin secretion
Pancreatic secretion
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 545481Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003433)
Ref 528964Cholecystokinin antagonists: (R)-tryptophan-based hybrid antagonists of high affinity and selectivity for CCK-A receptors. J Med Chem. 1991 Dec;34(12):3350-9.

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