Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D05LCX
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| Former ID |
DIB012151
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| Drug Name |
A-70276
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| Synonyms |
A-71134
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| Indication | Gastrointestinal disease [ICD10:K00-K93] | Terminated | [1] | ||
| Company |
Abbott Laboratories
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
n1c2c(c(cc1C(=O)N[C@@H](C(=O)N(CCCCC)CCCCC)Cc1c[nH]c3c1<br />cccc3)O)cccc2O
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| CAS Number |
CAS 127387-81-9
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| Target and Pathway | |||||
| Target(s) | Cholecystokinin receptor type A | Target Info | Modulator | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Insulin secretion | |||||
| Pancreatic secretion | |||||
| Reactome | Peptide ligand-binding receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003433) | ||||
| REF 2 | Cholecystokinin antagonists: (R)-tryptophan-based hybrid antagonists of high affinity and selectivity for CCK-A receptors. J Med Chem. 1991 Dec;34(12):3350-9. | ||||
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