Drug Information

Drug General Information
Drug ID
D05LPW
Former ID
DIB014779
Drug Name
DA-1229
Synonyms
DPP-IV inhibitor (tablet, type II diabetes), Dong-A
Drug Type
Small molecular drug
Indication Type 2 diabetes [ICD9: 250; ICD10:E11] Phase 1 [522762]
Company
Dong-A Pharmaceutical Co Ltd
Structure
Download
2D MOL

3D MOL
Formula
C19H26F3N3O3
Canonical SMILES
CC(C)(C)OCC1C(=O)NCCN1C(=O)CC(CC2=CC(=C(C=C2F)F)F)N
InChI
1S/C19H26F3N3O3/c1-19(2,3)28-10-16-18(27)24-4-5-25(16)17(26)8-12(23)6-11-7-14(21)15(22)9-13(11)20/h7,9,12,16H,4-6,8,10,23H2,1-3H3,(H,24,27)/t12-,16-/m1/s1
InChIKey
LCDDAGSJHKEABN-MLGOLLRUSA-N
PubChem Compound ID
25022354
PubChem Substance ID
56392536, 80964058, 131277233, 131347715, 138152339, 138152376, 162108731, 198960695, 224385582, 226678893, 246884363
Target and Pathway
Target(s) Dipeptidyl peptidase IV Target Info Inhibitor [531687]
KEGG Pathway Protein digestion and absorption
NetPath Pathway IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
References
Ref 522762ClinicalTrials.gov (NCT00961025) A Study to Characterize the Pharmacokinetics/Pharmacodynamics and Effect of Food of DA-1229 in Healthy Male Subjects. U.S. National Institutes of Health.
Ref 531687DA-1229, a novel and potent DPP4 inhibitor, improves insulin resistance and delays the onset of diabetes. Life Sci. 2012 Jan 2;90(1-2):21-9.

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