Drug Information

Drug General Information
Drug ID
D05MBZ
Former ID
DAP000086
Drug Name
Tamsulosin
Synonyms
Flomax; Flowmax; Harnal; Tamsolusin; Tamsulon; Tamsulosina; Tamsulosine; Tamsulosinum; Flomax (TN); Flomaxtra (TN); Tamsulon (TN); Tamsulosin (INN); Tamsulosin [INN:BAN]; Tamsulosina [INN-Spanish]; Tamsulosine [INN-French]; Tamsulosinum [INN-Latin]; Urimax (TN); (R)-5-(2-((2-(2-Ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide; 5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide; 5-[(2R)-2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide; 5-[(2R)-2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl]-2-methoxybenzenesulfonamide; 5-[2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2-methoxy-benzenesulfonamide; 5-{(2R)-2-[(2-{[2-(ethyloxy)phenyl]oxy}ethyl)amino]propyl}-2-(methyloxy)benzenesulfonamide
Drug Type
Small molecular drug
Indication Benign prostatic hyperplasia [ICD9: 600; ICD10:N40] Approved [468085], [536610]
Therapeutic Class
Anticancer Agents
Company
Yamanouchi Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C20H28N2O5S
InChI
InChI=1S/C20H28N2O5S/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24)/t15-/m1/s1
InChIKey
DRHKJLXJIQTDTD-OAHLLOKOSA-N
CAS Number
CAS 106133-20-4
PubChem Compound ID
129211
PubChem Substance ID
9334, 7978548, 10242264, 14855214, 14855215, 29308096, 46507763, 48416590, 49658919, 49881530, 50112696, 57342917, 77491402, 92309311, 93166419, 94568973, 96025245, 103219988, 103956570, 104369951, 117870725, 118048890, 124772213, 124893313, 126662035, 127253628, 127253629, 127253630, 127253631, 127253632, 127253633, 127253634, 127775697, 131293768, 131322925, 131549270, 134223415, 134337414, 135047731, 135651350, 137001370, 142769217, 143493354, 152164201, 152235887, 160826144, 160964050, 163092709, 163388355, 164786761
ChEBI ID
ChEBI:9398
SuperDrug ATC ID
G04CA02
SuperDrug CAS ID
cas=106133204
Target and Pathway
Target(s) Alpha-1A adrenergic receptor Target Info Modulator [556264]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
AMPK signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretion
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
AMPK Signaling
References
Ref 468085(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 488).
Ref 536610Alpha blockers for the treatment of benign prostatic hyperplasia. Rev Urol. 2007 Fall;9(4):181-90.
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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