Drug Information

Drug General Information
Drug ID
D05MEW
Former ID
DNC006954
Drug Name
N-(1-benzylpiperidin-4-yl)-3,5-dimethoxybenzamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528347]
Structure
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2D MOL

3D MOL
Formula
C21H26N2O3
Canonical SMILES
COC1=CC(=CC(=C1)C(=O)NC2CCN(CC2)CC3=CC=CC=C3)OC
InChI
1S/C21H26N2O3/c1-25-19-12-17(13-20(14-19)26-2)21(24)22-18-8-10-23(11-9-18)15-16-6-4-3-5-7-16/h3-7,12-14,18H,8-11,15H2,1-2H3,(H,22,24)
InChIKey
CBCISEXIJPDIBB-UHFFFAOYSA-N
PubChem Compound ID
14514271
Target and Pathway
Target(s) Melanin-concentrating hormone receptor 1 Target Info Inhibitor [528347]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 528347Bioorg Med Chem Lett. 2006 Oct 15;16(20):5445-50. Epub 2006 Aug 1.Identification of substituted 4-aminopiperidines and 3-aminopyrrolidines as potent MCH-R1 antagonists for the treatment of obesity.
Ref 528347Bioorg Med Chem Lett. 2006 Oct 15;16(20):5445-50. Epub 2006 Aug 1.Identification of substituted 4-aminopiperidines and 3-aminopyrrolidines as potent MCH-R1 antagonists for the treatment of obesity.

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