Drug General Information
Drug ID	D05OTZ
Former ID	DIB010599
Drug Name	SMP-986
Synonyms	Afacifenacin
Indication	Overactive bladder disorder [ICD9: 188, 596.51; ICD10:C67, N32.81]		Phase 2	[548182]
Company	Sumitomo Pharmaceuticals Co Ltd
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C(F)(F)(Oc1cc(CN2CCC(N3[C@H](c4ccccc4NC3=O)c3ccccc3)CC2<br />)ccc1)F
Target and Pathway
Target(s)	Sodium channel	Target Info	Antagonist	[551635]
	Muscarinic receptor	Target Info	Antagonist	[551635]
KEGG Pathway	Dopaminergic synapsehsa04020:Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	PI3K-Akt signaling pathway
	Cholinergic synapse
	Regulation of actin cytoskeleton
PathWhiz Pathway	Muscle/Heart Contraction
Reactome	Interaction between L1 and AnkyrinsR-HSA-390648:Muscarinic acetylcholine receptors
	Acetylcholine regulates insulin secretion
	G alpha (q) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	Regulation of Actin Cytoskeleton
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Secretion of Hydrochloric Acid in Parietal Cells
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 548182	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022820)
Ref 551635	DUAL INHIBITION OF Na+-CHANNEL AND MUSCARINIC RECEPTORS BY SMP-986 EFFICIENTLY IMPROVED VOIDING FUNCTION COMPARED TO ANTI-MUSCARINIC AGENTS IN TWO CONSCIOUS RAT MODELS OF DETRUSOR OVERACTIVITY. The Journal of Urology Volume 179, Issue 4, Supplement, April 2008, Pages 129.

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