TTD | Drug: D05PIX

Drug General Information
Drug ID	D05PIX
Former ID	DIB001583
Drug Name	CG-400549
Synonyms	CG-400329; CG-400462; CG-400587; Bacterial enoyl-ACP reductase inhibitors, CrystalGenomics; FabI inhibitors (antibacterial), CrystalGenomics; FabK inhibitors (bacterial infections, oral), CrystalGenomics
Drug Type	Small molecular drug
Indication	Bacterial infections [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104; ICD10:A00-B99]		Phase 2	[523897]
Company	Cg pharmaceuticals
Structure		Download 2D MOL 3D MOL
Formula	C19H20N2O2S
Canonical SMILES	s1c(ccc1)CCOc1ccn(c(=O)c1)Cc1cccc(c1C)N
PubChem Compound ID	11844916
Target and Pathway
Target(s)	Staphylococcus aureus Enoyl ACP reductase	Target Info	Inhibitor	[528783]
KEGG Pathway	Fatty acid biosynthesis
	Biotin metabolism
	Metabolic pathways
	Fatty acid metabolism
References
Ref 523897	ClinicalTrials.gov (NCT01593761) Phase 2a Study of CG400549 for the Treatment of cABSSSI Caused by Methicillin-resistant Staphylococcus Aureus. U.S. National Institutes of Health.
Ref 528783	In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea. Antimicrob Agents Chemother. 2007 Jul;51(7):2591-3. Epub 2007 Apr 9.

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Drug Information