Drug Information

Drug General Information
Drug ID
D05QHL
Former ID
DCL000986
Drug Name
Sivelestat sodium hydrate
Synonyms
Elaspol; Sivelestat sodium; LY544349 Sodium Hydrate; Ono 5046; EI-546; Elaspol (TN); Sivelestat sodium (USAN); Sivelestat sodium hydrate (JAN); ONO-5046.Na; Sodium 2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetate tetrahydrate; Sodium ((2-(((4-((2,2-dimethylpropanoyl)oxy)phenyl)sulfonyl)amino)benzoyl)amino)acetate tetrahydrate; Glycine, N-(2-(((4-(2,2-dimethyl-1-oxopropoxy)phenyl)sulfonyl)amino)benzoyl)-, monosodium salt, tetrahydrate
Drug Type
Small molecular drug
Indication Acute lung injury; Acute respiratory distress syndrome [ICD9: 518.5, 518.82; ICD10:J80] Phase 4 [536361]
Company
ONO Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C20H29N2NaO11S
Canonical SMILES
CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NC<br />C(=O)[O-].O.O.O.O.[Na+]
InChI
1S/C20H22N2O7S.Na.4H2O/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24;;;;;/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24);;4*1H2/q;+1;;;;/p-1
InChIKey
PLHREJBSQUSUCW-UHFFFAOYSA-M
CAS Number
CAS 201677-61-4
PubChem Compound ID
23663985
PubChem Substance ID
7848980, 10253427, 12014432, 14934312, 46234170, 56039266, 57386948, 77060685, 92714191, 93302558, 113440824, 121278936, 126592378, 126624342, 126655598, 126670224, 134339418, 135114580, 144206123, 152040505, 152102776, 162181212, 165235284, 170465996, 184546383, 196106031, 198935522, 210275600, 210281259, 223394142, 223663430, 242585327, 252218912
Target and Pathway
Target(s) Leukocyte elastase Target Info Inhibitor [536500]
KEGG Pathway Transcriptional misregulation in cancer
Systemic lupus erythematosus
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
C-MYB transcription factor network
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
WikiPathways Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Human Complement System
Degradation of collagen
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 536500Emerging therapies for treatment of acute lung injury and acute respiratory distress syndrome. Expert Opin Emerg Drugs. 2007 Sep;12(3):461-77.

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