TTD | Drug: D05QKO

Drug General Information
Drug ID	D05QKO
Former ID	DIB012863
Drug Name	NBI-5788
Synonyms	Tiplimotide; CGP-77116; MSP-771; MSP-771A; APL (multiple sclerosis), Neurocrine/Novartis; Altered peptide ligand (MS), Neurocrine/Novartis
Indication	Multiple scierosis [ICD9: 340; ICD10:G35]		Phase 2	[521426]
Company	Neurocrine Biosciences Inc
Structure		Download 2D MOL 3D MOL
Formula	C87H142N24O21
Canonical SMILES	C(=O)(N1[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N2[C@H](C(=O<br />)O)CCC2)[C@H](O)C)CCCNC(=N)N)CCC1)[C@@H](NC(=O)[C@@H](N<br/>C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=<br />O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[<br />C@H]1N(C(=O)[C@@H](NC(=O)[C@H](N)C)CCCCN)CCC1)C(C)C)C(C<br />)C)Cc1nc[nH]c1)CC(C)C)Cc1ccccc1)C)CC(=O)N)[C@H](CC)C)C(<br />C)C)[C@H](O)C
PubChem Compound ID	25084501
Target and Pathway
Target(s)	Myelin basic protein	Target Info	Binder	[525908]
WikiPathways	MAPK Cascade
	Structural Pathway of Interleukin 1 (IL-1)
	Spinal Cord Injury
	Glial Cell Differentiation
	Neural Crest Differentiation
References
Ref 521426	ClinicalTrials.gov (NCT00001781) Safety, Tolerability, and Effectiveness of CGP77116 in Patients With Multiple Sclerosis (MS). U.S. National Institutes of Health.
Ref 525908	NBI-5788, an altered MBP83-99 peptide, induces a T-helper 2-like immune response in multiple sclerosis patients. Ann Neurol. 2000 Nov;48(5):758-65.

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Drug Information