Drug Information

Drug General Information
Drug ID
D05QTJ
Former ID
DNC000423
Drug Name
Chloroethylclonidine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [537921]
Structure
Download
2D MOL

3D MOL
Formula
C13H17Cl3N4
Canonical SMILES
CN(CCCl)CC1=CC(=C(C(=C1)Cl)NC2=NCCN2)Cl
InChI
1S/C13H17Cl3N4/c1-20(5-2-14)8-9-6-10(15)12(11(16)7-9)19-13-17-3-4-18-13/h6-7H,2-5,8H2,1H3,(H2,17,18,19)
InChIKey
XFDVJGKSQRUEEM-UHFFFAOYSA-N
CAS Number
CAS 98086-36-3
PubChem Compound ID
104973
PubChem Substance ID
10233703, 11110807, 15471003, 26755658, 44434528, 47285790, 47350430, 47954381, 50065430, 50110970, 51618293, 57337944, 85209019, 90341347, 92098494, 103100301, 103340708, 104373340, 117472294, 124749532, 124879335, 124879336, 129680080, 134339851, 135062207, 135089706, 162755894, 179235756, 198940830, 230066265, 241137222
Target and Pathway
Target(s) Alpha-2A adrenergic receptor Target Info Agonist [537921]
Alpha-2C adrenergic receptor Target Info Agonist [537921]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolismR-HSA-390696:Adrenoceptors
Surfactant metabolism
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
GPCR downstream signaling
References
Ref 537921Selective irreversible binding of chloroethylclonidine at alpha 1- and alpha 2-adrenoceptor subtypes. Mol Pharmacol. 1993 Dec;44(6):1165-70.
Ref 537921Selective irreversible binding of chloroethylclonidine at alpha 1- and alpha 2-adrenoceptor subtypes. Mol Pharmacol. 1993 Dec;44(6):1165-70.

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