Drug Information

Drug General Information
Drug ID
D05RGO
Former ID
DNC014228
Drug Name
H-Pro-Phe-Phe-NH2
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530745]
Structure
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2D MOL

3D MOL
Formula
C23H28N4O3
Canonical SMILES
C1CC(NC1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CC3=CC=CC=C3)C(=O<br />)N
InChI
1S/C23H28N4O3/c24-21(28)19(14-16-8-3-1-4-9-16)26-23(30)20(15-17-10-5-2-6-11-17)27-22(29)18-12-7-13-25-18/h1-6,8-11,18-20,25H,7,12-15H2,(H2,24,28)(H,26,30)(H,27,29)/t18-,19-,20-/m0/s1
InChIKey
GQTQFZUTXSDLLQ-UFYCRDLUSA-N
PubChem Compound ID
44611435
Target and Pathway
Target(s) Substance-P receptor Target Info Inhibitor [530745]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Measles
PANTHER Pathway CCKR signaling map ST
Reactome G alpha (q) signalling events
WikiPathways SIDS Susceptibility Pathways
Gastrin-CREB signalling pathway via PKC and MAPK
Spinal Cord Injury
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 530745J Med Chem. 2010 Mar 25;53(6):2383-9.Discovery of dipeptides with high affinity to the specific binding site for substance P1-7.
Ref 530745J Med Chem. 2010 Mar 25;53(6):2383-9.Discovery of dipeptides with high affinity to the specific binding site for substance P1-7.

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