Drug Information

Drug General Information
Drug ID
D05RQB
Former ID
DNC000238
Drug Name
Aphidicolin
Drug Type
Small molecular drug
Indication Discovery agent Discontinued in Phase 1 [545226]
Structure
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2D MOL

3D MOL
Formula
C20H34O4
Canonical SMILES
CC12CCC(C(C1CCC3C24CCC(C(C3)C4)(CO)O)(C)CO)O
InChI
1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13?,14?,15?,16-,17+,18+,19?,20+/m1/s1
InChIKey
NOFOAYPPHIUXJR-NPNXGXLRSA-N
CAS Number
CAS 38966-21-1
PubChem Compound ID
463725
PubChem Substance ID
615901, 50322558, 57405561, 109737243
Target and Pathway
Target(s) DNA polymerase (HSV-2) Target Info Inhibitor [537281], [537798]
References
Ref 545226Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002516)
Ref 537281Proteasome regulation of ULBP1 transcription. J Immunol. 2009 May 15;182(10):6600-9.
Ref 537798Characterization of an aphidicolin-resistant mutant of herpes simplex virus type 2 which induces an altered viral DNA polymerase. Virology. 1984 May;135(1):87-96.

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