Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D05SKE
|
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| Former ID |
DNC006460
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| Drug Name |
6-bromo-3-(pyridin-4-yl)-1H-indole
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C13H9BrN2
|
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| Canonical SMILES |
C1=CC2=C(C=C1Br)NC=C2C3=CC=NC=C3
|
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| InChI |
1S/C13H9BrN2/c14-10-1-2-11-12(8-16-13(11)7-10)9-3-5-15-6-4-9/h1-8,16H
|
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| InChIKey |
KLYDZCDPTMADJL-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Inosine-5'-monophosphate dehydrogenase 2 | Target Info | Inhibitor | [1] | |
| BioCyc Pathway | Purine nucleotides degradation | ||||
| Urate biosynthesis/inosine 5'-phosphate degradation | |||||
| Guanosine nucleotides de novo biosynthesis | |||||
| Superpathway of purine nucleotide salvage | |||||
| Purine nucleotides de novo biosynthesis | |||||
| Guanosine ribonucleotides de novo biosynthesis | |||||
| KEGG Pathway | Purine metabolism | ||||
| Drug metabolism - other enzymes | |||||
| Metabolic pathways | |||||
| PANTHER Pathway | De novo purine biosynthesis | ||||
| Reactome | Purine ribonucleoside monophosphate biosynthesis | ||||
| References | |||||
| REF 1 | Bioorg Med Chem Lett. 2006 May 1;16(9):2535-8. Epub 2006 Feb 17.Low molecular weight indole fragments as IMPDH inhibitors. | ||||
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