Drug Information

Drug General Information
Drug ID
D05SNR
Former ID
DNC006235
Drug Name
5-(pentylthio)thiazolo[4,5-d]pyrimidin-7-ol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527875]
Structure
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2D MOL

3D MOL
Formula
C10H13N3OS2
Canonical SMILES
CCCCCSC1=NC(=O)C2=C(N1)N=CS2
InChI
1S/C10H13N3OS2/c1-2-3-4-5-15-10-12-8-7(9(14)13-10)16-6-11-8/h6H,2-5H2,1H3,(H,12,13,14)
InChIKey
QONMYXCFINJDMT-UHFFFAOYSA-N
PubChem Compound ID
9837964
Target and Pathway
Target(s) High affinity interleukin-8 receptor B Target Info Inhibitor [527875]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Endocytosis
Epithelial cell signaling in Helicobacter pylori infection
NetPath Pathway TNFalpha Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Interleukin signaling pathway
Pathway Interaction Database IL8- and CXCR2-mediated signaling events
Reactome Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 527875Bioorg Med Chem Lett. 2006 Feb 15;16(4):960-3. Epub 2005 Nov 15.Hit-to-Lead studies: the discovery of potent, orally bioavailable thiazolopyrimidine CXCR2 receptor antagonists.
Ref 527875Bioorg Med Chem Lett. 2006 Feb 15;16(4):960-3. Epub 2005 Nov 15.Hit-to-Lead studies: the discovery of potent, orally bioavailable thiazolopyrimidine CXCR2 receptor antagonists.

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