Drug Information

Drug General Information
Drug ID
D05SSC
Former ID
DCL000513
Drug Name
Dalcetrapib
Synonyms
JTT 705; JTT-705; R-1658; RG-1658; RO-4607381; S-[2-[[1-(2-ethylbutyl)cyclohexanecarbonyl]amino]phenyl] 2-methylpropanethioate
Drug Type
Small molecular drug
Indication Dyslipidaemias; Hyperlipidaemia [ICD9: 272, 272.0-272.4; ICD10:E78] Phase 3 [522290]
Company
Roche
Structure
Download
2D MOL

3D MOL
Formula
C23H35NO2S
Canonical SMILES
CCC(CC)CC1(CCCCC1)C(=O)NC2=CC=CC=C2SC(=O)C(C)C
InChI
1S/C23H35NO2S/c1-5-18(6-2)16-23(14-10-7-11-15-23)22(26)24-19-12-8-9-13-20(19)27-21(25)17(3)4/h8-9,12-13,17-18H,5-7,10-11,14-16H2,1-4H3,(H,24,26)
InChIKey
YZQLWPMZQVHJED-UHFFFAOYSA-N
PubChem Compound ID
6918540
PubChem Substance ID
12015448, 14927643, 17194949, 43529910, 57371967, 79689040, 103294369, 103990387, 114788136, 124490448, 126671653, 126731316, 129871265, 134339100, 135261049, 136367976, 137157003, 142130542, 143495520, 144115880, 144221104, 152106359, 152159578, 152234923, 152258615, 160647450, 162011639, 162205179, 162221183, 163914131, 164194108, 165246672, 170498253, 174528320, 177748646, 180387047, 185972146, 198984686, 198991964, 223471416, 223664086, 226840175, 241051420, 251971148, 252160607, 252215631, 252314519
Target and Pathway
Target(s) Cholesteryl ester transfer protein Target Info Inhibitor [551607]
PANTHER Pathway CCKR signaling map ST
Reactome LDL-mediated lipid transport
HDL-mediated lipid transport
WikiPathways Statin Pathway
Lipid digestion, mobilization, and transport
References
Ref 522290ClinicalTrials.gov (NCT00658515) A Study of RO4607381 in Stable Coronary Heart Disease Patients With Recent Acute Coronary Syndrome. U.S. National Institutes of Health.
Ref 551607Clinical pipeline report, company report or official report of Roche (2009).

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