Drug Information

Drug General Information
Drug ID
D05UKK
Former ID
DIB001653
Drug Name
FK-888
Drug Type
Small molecular drug
Indication Migraine [ICD9: 346; ICD10:G43] Discontinued in Phase 2 [539339], [545042]
Company
Fujisawa Pharmaceutical Co Ltd
Structure
Download
2D MOL

3D MOL
Formula
C36H36N4O4
InChI
InChI=1S/C36H36N4O4/c1-38-23-30(29-14-8-9-15-32(29)38)35(43)40-22-28(41)20-33(40)34(42)37-31(36(44)39(2)21-24-10-4-3-5-11-24)19-25-16-17-26-12-6-7-13-27(26)18-25/h3-18,23,28,31,33,41H,19-22H2,1-2H3,(H,37,42)/t28-,31+,33+/m1/s1
InChIKey
BFNKQTIJVFGCKQ-PDJGWCFMSA-N
CAS Number
CAS 138449-07-7
PubChem Compound ID
107967
PubChem Substance ID
10234528, 12014638, 14789092, 29215537, 44436885, 47957440, 50076531, 57338353, 78707672, 85788703, 104380156, 134221753, 135066043, 135650263, 135698071, 162023398, 233621956, 241375909, 242223933, 249617555, 252156481
Target and Pathway
Target(s) Substance-P receptor Target Info Antagonist [526652]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Measles
PANTHER Pathway CCKR signaling map ST
Reactome G alpha (q) signalling events
WikiPathways SIDS Susceptibility Pathways
Gastrin-CREB signalling pathway via PKC and MAPK
Spinal Cord Injury
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 539339(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2114).
Ref 545042Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001953)
Ref 526652Pharmacological profile of a high affinity dipeptide NK1 receptor antagonist, FK888. Br J Pharmacol. 1992 Nov;107(3):785-9.

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