Drug Information

Drug General Information
Drug ID
D05UYQ
Former ID
DNCL003577
Drug Name
Camicinal
Synonyms
962040
Drug Type
Small molecular drug
Indication Delayed gastric emptying; Gastroparesis [ICD9: 536.3; ICD10:K31.8] Phase 2 [524864], [540638]
Company
GlaxoSmithKline
Structure
Download
2D MOL
Formula
C25H33FN4O
InChI
InChI=1S/C25H33FN4O/c1-19-17-29(14-11-27-19)18-21-7-5-20(6-8-21)15-25(31)30-12-9-23(10-13-30)28-24-4-2-3-22(26)16-24/h2-8,16,19,23,27-28H,9-15,17-18H2,1H3/t19-/m0/s1
InChIKey
RZKDEGZIFSJVNA-IBGZPJMESA-N
PubChem Compound ID
15984937
PubChem Substance ID
24264147, 26573482, 36168710, 103590963, 104134529, 125240984, 134339036, 135267381, 137397655, 172232424, 178100860, 198965694, 210274732, 210280366, 224251212, 227887563, 245726454
Target and Pathway
Target(s) Motilin receptor Target Info Modulator [543753]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 524864ClinicalTrials.gov (NCT02210000) A Study to Evaluate the Effect of Camicinal on Gastroparesis Symptoms in Type 1 and 2 Diabetic Subjects With Gastroparesis. U.S. National Institutes of Health.
Ref 540638(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4035).
Ref 543753(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 297).

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