Drug Information

Drug General Information
Drug ID
D05UYW
Former ID
DAP000775
Drug Name
Dorzolamide
Synonyms
Trusopt; Dorzolamide (DZA); Dorzolamide (INN); Trusopt (TN); (4S,6S)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide; (4S,6S)-4-(ethylamino)-6-methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide; (4S,6S)-4-Ethylamino-6-methyl-7,7-dioxo-4,5,6,7-tetrahydro-7lambda*6*-thieno[2,3-b]thiopyran-2-sulfonic acid amide; (4S,trans)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide; (4S-TRANS)-4-(ETHYLAMINO)-5,6-DIHYDRO-6-METHYL-4H-THIENO(2,3-B)THIOPYRAN-2-SULFONAMIDE-7,7-DIOXIDE
Drug Type
Small molecular drug
Indication Open-angle glaucoma [ICD9: 365; ICD10:H40-H42] Approved [536361], [541892]
Therapeutic Class
Antihypertensive Agents
Company
Merck & Co
Structure
Download
2D MOL

3D MOL
Formula
C10H16N2O4S3
InChI
InChI=1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1
InChIKey
IAVUPMFITXYVAF-XPUUQOCRSA-N
CAS Number
CAS 120279-96-1
PubChem Compound ID
5284549
PubChem Substance ID
9183, 7887377, 7979124, 11039340, 11467144, 11468264, 11486852, 14752890, 14752891, 39317865, 46391654, 46506754, 46506976, 46511454, 47216874, 47589091, 47959869, 48334604, 48415919, 49699364, 50445654, 57359110, 85752887, 85787534, 92308962, 93166464, 93308959, 94569219, 96024567, 99313635, 104234231, 113863152, 117889294, 126652186, 131296245, 131858882, 134338060, 136062818, 137005797, 139083143, 162103346, 162180745, 162182114, 174006873, 174526418, 175267119, 176484076, 176484975, 178103416, 179149688
SuperDrug ATC ID
S01EC03
SuperDrug CAS ID
cas=120279961
Target and Pathway
Target(s) Carbonic anhydrase II Target Info Inhibitor [537461]
KEGG Pathway Nitrogen metabolism
Proximal tubule bicarbonate reclamation
Collecting duct acid secretion
Gastric acid secretion
Pancreatic secretion
Bile secretion
NetPath Pathway IL4 Signaling Pathway
EGFR1 Signaling Pathway
Reactome Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Reversible hydration of carbon dioxide
WikiPathways Reversible Hydration of Carbon Dioxide
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 541892(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6810).
Ref 537461Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. Bioorg Med Chem. 2009 Jul 15;17(14):5054-8. Epub 2009 May 30.

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