Drug Information

Drug General Information
Drug ID
D05VDI
Former ID
DIB002130
Drug Name
Aggrecanase-2 inhibitors
Synonyms
Aggrecanase-2 inhibitors (osteoarthritis); Aggrecanase-2 inhibitors (osteoarthritis), Array BioPharma/Japan Tobacco
Indication Osteoarthritis [ICD9: 715; ICD10:M15-M19, M47] Investigative [552056]
Company
Array BioPharma Inc
Structure
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2D MOL

3D MOL
Canonical SMILES
O=S(=O)(N[C@@]1([C@@]([C@H]1C)(C)c1ccccc1)C(=O)O)N1CCc2<br />c(C1)nc1n2ccc(c1)F
Target and Pathway
Target(s) Aggrecanase Target Info Inhibitor [543458]
Reactome Degradation of the extracellular matrix
O-glycosylation of TSR domain-containing proteins
WikiPathways Endochondral Ossification
Vitamin D Receptor Pathway
References
Ref 552056Synthesis and SAR of 2-phenyl-1-sulfonylaminocyclopropane carboxylates as ADAMTS-5 (Aggrecanase-2) inhibitors. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6213-7
Ref 543458(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1678).

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