Drug General Information
Drug ID	D05VEH
Drug Name	detirelix
Synonyms	102583-46-0; 89662-30-6; RS-68439; detirelix; detirelix acetate
Drug Type	Small molecular drug
Indication	Unspecified		Investigative	[1559759], [1560044]
Structure		Download 2D MOL
Formula	C78H105ClN18O13
PubChem Compound ID	70691429
Target and Pathway
Target(s)	Gonadotropin-releasing hormone receptor	Target Info	Modulator
KEGG Pathway	Neuroactive ligand-receptor interaction
	GnRH signaling pathway
NetPath Pathway	IL1 Signaling Pathway
	IL2 Signaling Pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome	Hormone ligand-binding receptors
	G alpha (q) signalling events
WikiPathways	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 1559759	Gonadotropin-releasing hormone receptor-targeted paclitaxel-degarelix conjugate: synthesis and in vitro evaluation.J Pept Sci.2015 Jul;21(7):569-76.
Ref 1560044	Inhibition of follicular development by a potent antagonistic analog of gonadotropin-releasing hormone (detirelix).

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